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That said, easier ePA may allow payers to implement more nuanced criteria (since they can manage more cases electronically) or to scale up specialty programs

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In addition to the role of iron metabolism in ferroptosis, an increasing number of other metabolic pathways have been implicated in ferroptosis, including the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis, the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH 4 )/dihydrofolate reductase (DHFR) axis, and the ferroptosis suppressor protein 1 (FSP1)/ coenzyme Q (CoQ) axis [8]

Altyar AE, Kensara OA, Sayed AA, Aleya L, Almutairi MH, Zaazouee MS, et al